Functionality of the progesterone receptor in ovarian cancer and its regulation by estrogen

Here, we sought to obtain evidence that the progesterone receptor (PR) may be functional in ovarian cancer and regulated by estrogen. Megestrol acetate inhibited growth of the PR-positive PE04 ovarian carcinoma xenograft but not the PR-negative HOX 60 xenograft. PR concentration was higher in early-...

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Veröffentlicht in:	Clinical cancer research 1998-09, Vol.4 (9), p.2245-2251
Hauptverfasser:	LANGDON, S. P, GABRA, H, BARTLETT, J. M. S, RABIAZ, G. J, HAWKINS, R. A, TESDALE, A. L, RITCHIE, A. A, MILLER, W. R, SMYTH, J. F
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cell Division - drug effects Estradiol - pharmacology Estrogens - physiology Female Female genital diseases Gynecology. Andrology. Obstetrics Humans Immunoenzyme Techniques Male Medical sciences Megestrol Acetate - pharmacology Mice Mice, Nude Neoplasm Transplantation Ovarian Neoplasms - drug therapy Ovarian Neoplasms - pathology Ovarian Neoplasms - ultrastructure Receptors, Estrogen - physiology Receptors, Progesterone - drug effects Receptors, Progesterone - metabolism Receptors, Progesterone - physiology Transplantation, Heterologous Tumor Cells, Cultured Tumors
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Zusammenfassung:	Here, we sought to obtain evidence that the progesterone receptor (PR) may be functional in ovarian cancer and regulated by estrogen. Megestrol acetate inhibited growth of the PR-positive PE04 ovarian carcinoma xenograft but not the PR-negative HOX 60 xenograft. PR concentration was higher in early-stage (I/II) tumors than in advanced-stage (III/IV) tumors (P = 0.007) and in tumors of endometrioid histology compared to other carcinoma subtypes (P = 0.009). Patients with a tumor PR concentration of >40 fmol/mg protein had significantly improved survival over those patients whose tumors contained
ISSN:	1078-0432 1557-3265