Cellular target of UVB-induced DNA damage resulting in local suppression of contact hypersensitivity

Cellular target of UVB-induced DNA damage resulting in local suppression of contact hypersensitivity

Experimental data are reviewed that lend support to the hypothesis that formation of DNA damage is the initiation event of local suppression of contact hypersensitivity (CHS) after exposure to ultraviolet (UV) radiaton and that the antigen-presenting cell (APC) is an important traget for this DNA da...

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Veröffentlicht in:Journal of photochemistry and photobiology. B, Biology Biology, 1998-07, Vol.44 (2), p.107-111
Hauptverfasser: Vink, Arie A., Shreedhar, Vijay, Roza, L., Krutmann, Jean, Kripke, Margaret L.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Antigen-presenting cells
Cells, Cultured
Contact hypersensitivity
Dermatitis, Contact - genetics
Dermatitis, Contact - immunology
DNA - radiation effects
DNA Damage
Humans
Immunosuppression
Models, Genetic
Models, Immunological
Photoimmunology
Ultraviolet Rays
UVB
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Beschreibung
Zusammenfassung:Experimental data are reviewed that lend support to the hypothesis that formation of DNA damage is the initiation event of local suppression of contact hypersensitivity (CHS) after exposure to ultraviolet (UV) radiaton and that the antigen-presenting cell (APC) is an important traget for this DNA damage.
ISSN:1011-1344
1873-2682
DOI:10.1016/S1011-1344(98)00128-6