Blockade of β-adrenoceptors enhances cAMP signal transduction in vivo

The aim of this study was to determine whether the blockade of β-adrenoceptors would enhance cAMP-mediated signal transduction processes in vivo. The administration of the membrane permeable cAMP analogue, 8-(4-chlorophenylthiol)-cAMP (8-CPT-cAMP, 10 μmol/kg, i.v.) produced an increase in heart rate...

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Veröffentlicht in:	European journal of pharmacology 1998-08, Vol.355 (2), p.189-193
Hauptverfasser:	Whalen, Erin J, Johnson, Alan Kim, Lewis, Stephen J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic beta-Antagonists - pharmacology Animals Biological and medical sciences Blood Pressure - drug effects Cyclic AMP - analogs & derivatives Cyclic AMP - pharmacology Fundamental and applied biological sciences. Psychology Heart Heart Rate - drug effects Hemodynamics. Rheology In vivo Nitric oxide (NO) Propranolol - pharmacology Rats Rats, Sprague-Dawley Receptors, Adrenergic, beta - drug effects Receptors, Adrenergic, beta - physiology Signal Transduction - drug effects Space life sciences Thionucleotides - pharmacology Vascular Resistance - drug effects Vasculature Vertebrates: cardiovascular system β-Adrenoceptor
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Zusammenfassung:	The aim of this study was to determine whether the blockade of β-adrenoceptors would enhance cAMP-mediated signal transduction processes in vivo. The administration of the membrane permeable cAMP analogue, 8-(4-chlorophenylthiol)-cAMP (8-CPT-cAMP, 10 μmol/kg, i.v.) produced an increase in heart rate (+27±2%, P
ISSN:	0014-2999 1879-0712
DOI:	10.1016/S0014-2999(98)00517-2