Effects of hydroxytamoxifen and tamoxifen on peroxidase activity in the immature rat uterus
Hydroxytamoxifen (1–10 μg) induces peroxidase activity in the estrogen-primed, immature rat uterus. Tamoxifen itself (1–100 μg) shows relatively little activity but it inhibits the stimulation caused by the hydroxy compound. This antioestrogenic action of tamoxifen does not therefore involve convers...
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| Veröffentlicht in: | Journal of steroid biochemistry 1982, Vol.16 (1), p.125-127 |
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| container_end_page | 127 |
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| container_issue | 1 |
| container_start_page | 125 |
| container_title | Journal of steroid biochemistry |
| container_volume | 16 |
| creator | Vass, M.A. Green, B. |
| description | Hydroxytamoxifen (1–10 μg) induces peroxidase activity in the estrogen-primed, immature rat uterus. Tamoxifen itself (1–100 μg) shows relatively little activity but it inhibits the stimulation caused by the hydroxy compound. This antioestrogenic action of tamoxifen does not therefore involve conversion to the monohydroxylated metabolite. |
| doi_str_mv | 10.1016/0022-4731(82)90153-4 |
| format | Article |
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Tamoxifen itself (1–100 μg) shows relatively little activity but it inhibits the stimulation caused by the hydroxy compound. This antioestrogenic action of tamoxifen does not therefore involve conversion to the monohydroxylated metabolite.</description><identifier>ISSN: 0022-4731</identifier><identifier>DOI: 10.1016/0022-4731(82)90153-4</identifier><identifier>PMID: 7062735</identifier><language>eng</language><publisher>England: Elsevier B.V</publisher><subject>Animals ; Estrogen Antagonists - pharmacology ; Female ; Organ Size - drug effects ; Peroxidases - metabolism ; Rats ; Tamoxifen - analogs & derivatives ; Tamoxifen - pharmacology ; Uterus - drug effects ; Uterus - enzymology</subject><ispartof>Journal of steroid biochemistry, 1982, Vol.16 (1), p.125-127</ispartof><rights>1982</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-7add89cd0f47c717fa60126142b4fe3a8d38ec64f7ee86adf6c70bff8bf505753</citedby><cites>FETCH-LOGICAL-c357t-7add89cd0f47c717fa60126142b4fe3a8d38ec64f7ee86adf6c70bff8bf505753</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7062735$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vass, M.A.</creatorcontrib><creatorcontrib>Green, B.</creatorcontrib><title>Effects of hydroxytamoxifen and tamoxifen on peroxidase activity in the immature rat uterus</title><title>Journal of steroid biochemistry</title><addtitle>J Steroid Biochem</addtitle><description>Hydroxytamoxifen (1–10 μg) induces peroxidase activity in the estrogen-primed, immature rat uterus. Tamoxifen itself (1–100 μg) shows relatively little activity but it inhibits the stimulation caused by the hydroxy compound. This antioestrogenic action of tamoxifen does not therefore involve conversion to the monohydroxylated metabolite.</description><subject>Animals</subject><subject>Estrogen Antagonists - pharmacology</subject><subject>Female</subject><subject>Organ Size - drug effects</subject><subject>Peroxidases - metabolism</subject><subject>Rats</subject><subject>Tamoxifen - analogs & derivatives</subject><subject>Tamoxifen - pharmacology</subject><subject>Uterus - drug effects</subject><subject>Uterus - enzymology</subject><issn>0022-4731</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1982</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1PwzAMhnMAjTH4ByDlhOBQSJq0SS9IaBof0iQucOIQZYmjBa3tSFK0_ns6No0bB8uy_b62_CB0QcktJbS8IyTPMy4YvZb5TUVowTJ-hMaH9gk6jfGTEFpJno_QSJAyF6wYo4-Zc2BSxK3Dy96GdtMnXbcb76DBurH4r2obvIZB4K2OgLVJ_tunHvsGpyVgX9c6dQFw0Al3CUIXz9Cx06sI5_s8Qe-Ps7fpczZ_fXqZPswzwwqRMqGtlZWxxHFhBBVOl4TmJeX5gjtgWlomwZTcCQBZautKI8jCOblwBSlEwSboard3HdqvDmJStY8GVivdQNtFJVjFWDnEBPGd0IQ2xgBOrYOvdegVJWrLUW2BqS0wJXP1y1HxwXa5398tarAH0x7iML_fzWF48ttDUNF4aAxYHwa2yrb-_wM_POCF1g</recordid><startdate>1982</startdate><enddate>1982</enddate><creator>Vass, M.A.</creator><creator>Green, B.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1982</creationdate><title>Effects of hydroxytamoxifen and tamoxifen on peroxidase activity in the immature rat uterus</title><author>Vass, M.A. ; Green, B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-7add89cd0f47c717fa60126142b4fe3a8d38ec64f7ee86adf6c70bff8bf505753</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1982</creationdate><topic>Animals</topic><topic>Estrogen Antagonists - pharmacology</topic><topic>Female</topic><topic>Organ Size - drug effects</topic><topic>Peroxidases - metabolism</topic><topic>Rats</topic><topic>Tamoxifen - analogs & derivatives</topic><topic>Tamoxifen - pharmacology</topic><topic>Uterus - drug effects</topic><topic>Uterus - enzymology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vass, M.A.</creatorcontrib><creatorcontrib>Green, B.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of steroid biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vass, M.A.</au><au>Green, B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of hydroxytamoxifen and tamoxifen on peroxidase activity in the immature rat uterus</atitle><jtitle>Journal of steroid biochemistry</jtitle><addtitle>J Steroid Biochem</addtitle><date>1982</date><risdate>1982</risdate><volume>16</volume><issue>1</issue><spage>125</spage><epage>127</epage><pages>125-127</pages><issn>0022-4731</issn><abstract>Hydroxytamoxifen (1–10 μg) induces peroxidase activity in the estrogen-primed, immature rat uterus. Tamoxifen itself (1–100 μg) shows relatively little activity but it inhibits the stimulation caused by the hydroxy compound. This antioestrogenic action of tamoxifen does not therefore involve conversion to the monohydroxylated metabolite.</abstract><cop>England</cop><pub>Elsevier B.V</pub><pmid>7062735</pmid><doi>10.1016/0022-4731(82)90153-4</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-4731 |
| ispartof | Journal of steroid biochemistry, 1982, Vol.16 (1), p.125-127 |
| issn | 0022-4731 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_73933693 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Animals Estrogen Antagonists - pharmacology Female Organ Size - drug effects Peroxidases - metabolism Rats Tamoxifen - analogs & derivatives Tamoxifen - pharmacology Uterus - drug effects Uterus - enzymology |
| title | Effects of hydroxytamoxifen and tamoxifen on peroxidase activity in the immature rat uterus |
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