Effects of hydroxytamoxifen and tamoxifen on peroxidase activity in the immature rat uterus

Effects of hydroxytamoxifen and tamoxifen on peroxidase activity in the immature rat uterus

Hydroxytamoxifen (1–10 μg) induces peroxidase activity in the estrogen-primed, immature rat uterus. Tamoxifen itself (1–100 μg) shows relatively little activity but it inhibits the stimulation caused by the hydroxy compound. This antioestrogenic action of tamoxifen does not therefore involve convers...

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Veröffentlicht in:Journal of steroid biochemistry 1982, Vol.16 (1), p.125-127
Hauptverfasser: Vass, M.A., Green, B.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Estrogen Antagonists - pharmacology
Female
Organ Size - drug effects
Peroxidases - metabolism
Rats
Tamoxifen - analogs & derivatives
Tamoxifen - pharmacology
Uterus - drug effects
Uterus - enzymology
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Zusammenfassung:Hydroxytamoxifen (1–10 μg) induces peroxidase activity in the estrogen-primed, immature rat uterus. Tamoxifen itself (1–100 μg) shows relatively little activity but it inhibits the stimulation caused by the hydroxy compound. This antioestrogenic action of tamoxifen does not therefore involve conversion to the monohydroxylated metabolite.
ISSN:0022-4731
DOI:10.1016/0022-4731(82)90153-4