Iodine-125--Labeled Triiodothyronine in Rat Brain: Evidence for Localization in Discrete Neural Systems

Autoradiograms prepared from adult rat brains demonstrate that nerve cells and neuropil in different brain regions selectively concentrate and retain intravenously administered triiodothyronine, by mechanisms susceptible to saturation with excess triiodothyronine. A neuroregulatory role for thyroid...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Science (American Association for the Advancement of Science) 1982-01, Vol.215 (4530), p.309-312
Hauptverfasser:	Dratman, Mary B., Futaesaku, Yataka, Crutchfield, Floy L., Berman, Nancy, Payne, Bertram, Sar, Madhabananda, Stumpf, Walter E.
Format:	Artikel
Sprache:	eng
Schlagworte:	550201 - Biochemistry- Tracer Techniques 551001 - Physiological Systems- Tracer Techniques ANIMAL CELLS ANIMALS Autoradiography BASIC BIOLOGICAL SCIENCES BETA DECAY RADIOISOTOPES BIOCHEMISTRY BIOLOGICAL LOCALIZATION BODY BRAIN Brain - cytology Brain - metabolism Brain Mapping Brain research CENTRAL NERVOUS SYSTEM CHEMISTRY DAYS LIVING RADIOISOTOPES ELECTRON CAPTURE RADIOISOTOPES HORMONES INTERMEDIATE MASS NUCLEI Intravenous injections IODINE 125 IODINE ISOTOPES ISOTOPE APPLICATIONS ISOTOPES LABELLED COMPOUNDS Magnification Male MAMMALS METABOLISM NERVE CELLS Nerves NERVOUS SYSTEM Neurons Neuropil NUCLEI ODD-EVEN NUCLEI ORGANS PEPTIDE HORMONES Perceptual localization PHYSIOLOGY Purkinje cells Pyramidal cells Radioactive decay RADIOISOTOPES RATS Rats, Inbred Strains RODENTS SENSITIVITY SOMATIC CELLS THYROID HORMONES TRIIODOTHYRONINE Triiodothyronine - metabolism VERTEBRATES
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Autoradiograms prepared from adult rat brains demonstrate that nerve cells and neuropil in different brain regions selectively concentrate and retain intravenously administered triiodothyronine, by mechanisms susceptible to saturation with excess triiodothyronine. A neuroregulatory role for thyroid hormones, strongly supported by the observations, may account for their marked effects on behavior and the activity of the autonomic nervous system.
ISSN:	0036-8075 1095-9203
DOI:	10.1126/science.7053582