UV-Guided Isolation of Alantrypinone, a Novel Penicillium Alkaloid

Fumiquinazoline F (1) and alantrypinone (2) have been isolated as the two major metabolites of Penicillium thymicola. The structure of 2, which contains a new ring structure, was elucidated by analysis of spectroscopic data including 2D NMR. The absolute configuration of 2 was established by a singl...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 1998-09, Vol.61 (9), p.1154-1157
Hauptverfasser:	Larsen, Thomas Ostenfeld, Frydenvang, Karla, Frisvad, Jens Christian, Christophersen, Carsten
Format:	Artikel
Sprache:	eng
Schlagworte:	ALKALOIDS Alkaloids - chemistry Alkaloids - isolation & purification AURANTHINE Biological and medical sciences Carbohydrate Sequence CHEMICAL COMPOSITION CHEMICAL STRUCTURE Crystallography, X-Ray FUMIQUINZOLINE F Fundamental and applied biological sciences. Psychology GLYANTRYPINE Indoles Magnetic Resonance Spectroscopy METABOLITES Microbiology Molecular Conformation Molecular Sequence Data Morphology, structure, chemical composition Mycology PENICILLIUM Penicillium - chemistry PENICILLIUM THYMICOLA PENICILLIUM VERRUCOSUM Quinazolines SECONDARY METABOLITES SPECTRAL ANALYSIS SPECTROMETRY Spectrophotometry, Ultraviolet
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Zusammenfassung:	Fumiquinazoline F (1) and alantrypinone (2) have been isolated as the two major metabolites of Penicillium thymicola. The structure of 2, which contains a new ring structure, was elucidated by analysis of spectroscopic data including 2D NMR. The absolute configuration of 2 was established by a single-crystal X-ray diffraction study.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np980056v