Plasmodium berghei: Acid-insensitive phosphofructokinase in infected mouse erythrocytes

The rate of glucose utilization by red blood cells infected with Plasmodium berghei was not inhibited by an acidic pH which completely inhibited normal red cell glucose consumption. This insensitivity to acid conditions by P. berghei-parasitized red cells was associated with an electrophoretically s...

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Veröffentlicht in:	Experimental parasitology 1982-01, Vol.53 (1), p.11-16
Hauptverfasser:	Sander, Barry J., Lowery, Mary Sue, Kruckeberg, Walter C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Electrophoresis, Starch Gel enzymes Erythrocytes - enzymology Erythrocytes - metabolism Erythrocytes - parasitology Glucose consumption Glycolysis Hydrogen-Ion Concentration Malaria Male metabolism Mice Mouse erythrocyte Phosphofructokinase (EC 2.7.1.11) Phosphofructokinase-1 - blood Phosphofructokinase-1 - metabolism Plasmodium berghei Plasmodium berghei - enzymology Protozoa Protozoa, parasitic
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Zusammenfassung:	The rate of glucose utilization by red blood cells infected with Plasmodium berghei was not inhibited by an acidic pH which completely inhibited normal red cell glucose consumption. This insensitivity to acid conditions by P. berghei-parasitized red cells was associated with an electrophoretically separable and kinetically distinct form of the enzyme phosphofructokinase (EC 2.7.1.11) which exhibited a pH response similar to that of whole-cell glucose consumption.
ISSN:	0014-4894 1090-2449
DOI:	10.1016/0014-4894(82)90087-X