Indole alkaloids from the tunicate Aplidium meridianum

Five new indole alkaloids, meridianins A-E (1-5), have been isolated from the tunicate Aplidium meridianum, which was collected at a depth of 100 m near the South Georgia Islands, and their structures were elucidated by spectroscopic techniques. Compounds 2-5 showed cytotoxicity toward murine tumor...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 1998-09, Vol.61 (9), p.1130-1132
Hauptverfasser:	Franco, L.H. (Universidad de Buenos Aires.), Kier Joffe, E.B. de, Puricelli, L, Tatian, M, Seldes, A.M, Palermo, J.A
Format:	Artikel
Sprache:	eng
Schlagworte:	ALKALOIDS Alkaloids - isolation & purification Alkaloids - pharmacology Animals ANTINEOPLASTIC AGENTS Antineoplastic Agents - isolation & purification Antineoplastic Agents - pharmacology AQUATIC ANIMALS Biological and medical sciences CELL CULTURE CELL LINES CHEMICAL COMPOSITION CHEMICAL STRUCTURE Chromatography, High Pressure Liquid CYTOTOXIC COMPOUNDS Drug Screening Assays, Antitumor FALKLAND ISLANDS (MALVINAS) General pharmacology Humans INDOLES INVERTEBRATES Magnetic Resonance Spectroscopy Mass Spectrometry Medical sciences MERIDIANINS Mice MURINE TUMOR CELL LINES PHARMACEUTICAL PRODUCTS Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments SOUTH GEORGIA ISLAND SPECTRAL ANALYSIS SPECTROMETRY Spectrophotometry, Ultraviolet TOXIC SUBSTANCES Tumor Cells, Cultured Urochordata - metabolism
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Beschreibung
Zusammenfassung:	Five new indole alkaloids, meridianins A-E (1-5), have been isolated from the tunicate Aplidium meridianum, which was collected at a depth of 100 m near the South Georgia Islands, and their structures were elucidated by spectroscopic techniques. Compounds 2-5 showed cytotoxicity toward murine tumor cell lines.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np970493u