Substance P Analog, DiMe-C7: Evidence for Stability in Rat Brain and Prolonged Central Actions

A metabolically protected analog of substance P, [pGlu$^{5}$-MePhe$^{8}$-MeGly$^{9}$]SP(5-11) (DiMe-C7), was approximately equipotent with substance P in causing increased locomotor activity after microinfusion into the ventral tegmental area of rat brain, but the effects of DiMe-C7 on behavior were...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1982-01, Vol.215 (4529), p.188-190
Hauptverfasser:	Eison, A. S., Iversen, S. D., Sandberg, B. E. B., Watson, S. P., Hanley, M. R., Iversen, L. L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Behavior, Animal - drug effects Brain Brain - metabolism Central nervous system Locomotion Metabolism Motor Activity - drug effects Peptide Fragments Pyrrolidonecarboxylic Acid - analogs & derivatives Radioactive decay Rats Substance P - analogs & derivatives Substance P - metabolism Substance P - pharmacology Substantia nigra Ventral tegmental area
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Zusammenfassung:	A metabolically protected analog of substance P, [pGlu$^{5}$-MePhe$^{8}$-MeGly$^{9}$]SP(5-11) (DiMe-C7), was approximately equipotent with substance P in causing increased locomotor activity after microinfusion into the ventral tegmental area of rat brain, but the effects of DiMe-C7 on behavior were considerably prolonged. There was little metabolic degradation of tritiated DiMe-C7 for up to 1 hour after infusion, whereas tritiated substance P was completely degraded within 10 minutes.
ISSN:	0036-8075 1095-9203
DOI:	10.1126/science.6171884