Microglia, but not astrocytes, react to sciatic nerve injury in aging rats

Peripheral nerve axotomy activates microglia and astrocytes within regions of brainstem or spinal cord from which the nerve arises. The present study demonstrates that unilateral sciatic axotomy in rats 2 to 18 months of age results in differing responses with age between these two glial populations...

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Veröffentlicht in:	Brain research 1998-09, Vol.806 (1), p.113-116
Hauptverfasser:	Gilmore, Shirley A, Kane, Cynthia J.M
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging - physiology Animals Astrocyte Astrocytes - physiology Axotomy Biological and medical sciences Development. Senescence. Regeneration. Transplantation Fundamental and applied biological sciences. Psychology Glial fibrillary acidic protein Glial Fibrillary Acidic Protein - metabolism Microglia Microglia - physiology Rats Reference Values Sciatic Nerve - injuries Sciatic nerve axotomy Spinal Cord - pathology Spinal Cord - physiopathology Vertebrates: nervous system and sense organs Wounds, Penetrating - pathology Wounds, Penetrating - physiopathology
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Beschreibung
Zusammenfassung:	Peripheral nerve axotomy activates microglia and astrocytes within regions of brainstem or spinal cord from which the nerve arises. The present study demonstrates that unilateral sciatic axotomy in rats 2 to 18 months of age results in differing responses with age between these two glial populations. By 4 days postaxotomy, both astrocytes and microglia become activated in 2-month-old rats, whereas only the microglial population shows evidence of activation in rats 8 to 18 months of age.
ISSN:	0006-8993 1872-6240
DOI:	10.1016/S0006-8993(98)00754-9