(Z,Z)-2,7-Bis(4-amidinobenzylidene)cycloheptan-1-one: Identification of a Highly Active Inhibitor of Blood Coagulation Factor Xa

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Veröffentlicht in:	Journal of medicinal chemistry 1998-09, Vol.41 (19), p.3551-3556
Hauptverfasser:	Shaw, Kenneth J, Guilford, William J, Dallas, Jerry L, Koovakkaat, Sunil K, McCarrick, Margaret A, Liang, Amy, Light, David R, Morrissey, Michael M
Format:	Artikel
Sprache:	eng
Schlagworte:	Amidines - chemistry Amidines - metabolism Amidines - pharmacology Amidines - radiation effects Animals Benzylidene Compounds - chemistry Benzylidene Compounds - metabolism Benzylidene Compounds - pharmacology Benzylidene Compounds - radiation effects Binding Sites Biological and medical sciences Blood. Blood coagulation. Reticuloendothelial system Cattle Factor Xa Inhibitors Humans Medical sciences Models, Molecular Molecular Conformation - radiation effects Pharmacology. Drug treatments Photochemistry Serine Proteinase Inhibitors - chemistry Serine Proteinase Inhibitors - metabolism Serine Proteinase Inhibitors - pharmacology Serine Proteinase Inhibitors - radiation effects Stereoisomerism Thrombin - antagonists & inhibitors Trypsin Inhibitors - chemistry Trypsin Inhibitors - metabolism Trypsin Inhibitors - pharmacology Trypsin Inhibitors - radiation effects
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