Long-term Within-Subject Variability of Inspiratory Neural Drive Response to Hypoxia

We analyze the within-subject variation of mouth occlusion pressure (P0.1) response to progressive isocapnic hypoxic stimulation over long time periods in normal subjects. We studied 21 healthy subjects (14 male and 7 female; aged 40±12 yrs) (mean±SD). Lung volumes, basal P0.1, and P0.1 response to...

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Veröffentlicht in:Chest 1998-08, Vol.114 (2), p.521-525
Hauptverfasser: Garciéa-Riéo, Francisco, Pino-Garciéa, José M., Racionero, Miguel A., Terreros-Caro, Javier G., Goémez-Mendieta, Mariéa A., Prados, Concepcioén, Villasante, Carlos
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Sprache:eng
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Zusammenfassung:We analyze the within-subject variation of mouth occlusion pressure (P0.1) response to progressive isocapnic hypoxic stimulation over long time periods in normal subjects. We studied 21 healthy subjects (14 male and 7 female; aged 40±12 yrs) (mean±SD). Lung volumes, basal P0.1, and P0.1 response to hypoxia were measured on two separate occasions 2 months apart, under similar ambient and clinical conditions. There was no significant change in clinical condition, FVC, FEV1, arterial oxygenation saturation, end-tidal and mixed venous Pco2 levels, or P0.1 between the two visits. The mean P0.1 responses to hypoxia in the two explorations were 0.032±0.022 and 0.034±0.022 kPa/%, respectively. There was a moderate intrasubject variability of P0.1 response to hypoxia, with a coefficient of reproducibility of 0.01 kPa/%. Power calculations to establish the optimal sample size required for hypoxic stimulation are presented. Long term within-subject variability of P0.1 response to hypoxia is moderate. This intrinsic variability needs to be emphasized when interpreting the effects of experimental interventions on hypoxic sensitivity.
ISSN:0012-3692
1931-3543
DOI:10.1378/chest.114.2.521