Long-term Within-Subject Variability of Inspiratory Neural Drive Response to Hypoxia
We analyze the within-subject variation of mouth occlusion pressure (P0.1) response to progressive isocapnic hypoxic stimulation over long time periods in normal subjects. We studied 21 healthy subjects (14 male and 7 female; aged 40±12 yrs) (mean±SD). Lung volumes, basal P0.1, and P0.1 response to...
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Veröffentlicht in: | Chest 1998-08, Vol.114 (2), p.521-525 |
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Sprache: | eng |
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Zusammenfassung: | We analyze the within-subject variation of mouth occlusion pressure (P0.1) response to progressive isocapnic hypoxic stimulation over long time periods in normal subjects.
We studied 21 healthy subjects (14 male and 7 female; aged 40±12 yrs) (mean±SD). Lung volumes, basal P0.1, and P0.1 response to hypoxia were measured on two separate occasions 2 months apart, under similar ambient and clinical conditions.
There was no significant change in clinical condition, FVC, FEV1, arterial oxygenation saturation, end-tidal and mixed venous Pco2 levels, or P0.1 between the two visits. The mean P0.1 responses to hypoxia in the two explorations were 0.032±0.022 and 0.034±0.022 kPa/%, respectively. There was a moderate intrasubject variability of P0.1 response to hypoxia, with a coefficient of reproducibility of 0.01 kPa/%. Power calculations to establish the optimal sample size required for hypoxic stimulation are presented.
Long term within-subject variability of P0.1 response to hypoxia is moderate. This intrinsic variability needs to be emphasized when interpreting the effects of experimental interventions on hypoxic sensitivity. |
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ISSN: | 0012-3692 1931-3543 |
DOI: | 10.1378/chest.114.2.521 |