ANTITUMOR AGENTS FROM STREPTOMYCES ANANDII: GILVOCARCINS V, M AND E
The isolation and structure elucidation of gilvocarcins V, M and E from Streptomyces anandii is reported. Solvent extraction and high performance liquid chromatography were employed along with NMR and X-ray crystallographic analysis. Gilvocarcins V and M showed antimicrobial activity while only gilv...
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| Veröffentlicht in: | Journal of antibiotics 1981, Vol.34(12), pp.1544-1555 |
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| container_end_page | 1555 |
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| container_issue | 12 |
| container_start_page | 1544 |
| container_title | Journal of antibiotics |
| container_volume | 34 |
| creator | BALITZ, D. M. O'HERRON, F. A. BUSH, J. VYAS, D. M. NETTLETON, D. E. GRULICH, R. E. BRADNER, W. T. DOYLE, T. W. ARNOLD, E. CLARDY, J. |
| description | The isolation and structure elucidation of gilvocarcins V, M and E from Streptomyces anandii is reported. Solvent extraction and high performance liquid chromatography were employed along with NMR and X-ray crystallographic analysis. Gilvocarcins V and M showed antimicrobial activity while only gilvocarcin V demonstrated potential as an antitumor agent. |
| doi_str_mv | 10.7164/antibiotics.34.1544 |
| format | Article |
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M. ; O'HERRON, F. A. ; BUSH, J. ; VYAS, D. M. ; NETTLETON, D. E. ; GRULICH, R. E. ; BRADNER, W. T. ; DOYLE, T. W. ; ARNOLD, E. ; CLARDY, J.</creator><creatorcontrib>BALITZ, D. M. ; O'HERRON, F. A. ; BUSH, J. ; VYAS, D. M. ; NETTLETON, D. E. ; GRULICH, R. E. ; BRADNER, W. T. ; DOYLE, T. W. ; ARNOLD, E. ; CLARDY, J.</creatorcontrib><description>The isolation and structure elucidation of gilvocarcins V, M and E from Streptomyces anandii is reported. Solvent extraction and high performance liquid chromatography were employed along with NMR and X-ray crystallographic analysis. 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| fulltext | fulltext |
| identifier | ISSN: 0021-8820 |
| ispartof | The Journal of Antibiotics, 1981, Vol.34(12), pp.1544-1555 |
| issn | 0021-8820 1881-1469 |
| language | eng |
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| source | MEDLINE; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese |
| subjects | Aminoglycosides Animals Anti-Bacterial Agents Antibiotics, Antineoplastic - isolation & purification Antibiotics, Antineoplastic - pharmacology Bacteria - drug effects Chemical Phenomena Chemistry Coumarins Glycosides - isolation & purification Glycosides - pharmacology Mice Streptomyces - metabolism |
| title | ANTITUMOR AGENTS FROM STREPTOMYCES ANANDII: GILVOCARCINS V, M AND E |
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