ANTITUMOR AGENTS FROM STREPTOMYCES ANANDII: GILVOCARCINS V, M AND E

The isolation and structure elucidation of gilvocarcins V, M and E from Streptomyces anandii is reported. Solvent extraction and high performance liquid chromatography were employed along with NMR and X-ray crystallographic analysis. Gilvocarcins V and M showed antimicrobial activity while only gilv...

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Veröffentlicht in:	Journal of antibiotics 1981, Vol.34(12), pp.1544-1555
Hauptverfasser:	BALITZ, D. M., O'HERRON, F. A., BUSH, J., VYAS, D. M., NETTLETON, D. E., GRULICH, R. E., BRADNER, W. T., DOYLE, T. W., ARNOLD, E., CLARDY, J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminoglycosides Animals Anti-Bacterial Agents Antibiotics, Antineoplastic - isolation & purification Antibiotics, Antineoplastic - pharmacology Bacteria - drug effects Chemical Phenomena Chemistry Coumarins Glycosides - isolation & purification Glycosides - pharmacology Mice Streptomyces - metabolism
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Zusammenfassung:	The isolation and structure elucidation of gilvocarcins V, M and E from Streptomyces anandii is reported. Solvent extraction and high performance liquid chromatography were employed along with NMR and X-ray crystallographic analysis. Gilvocarcins V and M showed antimicrobial activity while only gilvocarcin V demonstrated potential as an antitumor agent.
ISSN:	0021-8820 1881-1469
DOI:	10.7164/antibiotics.34.1544