Uracil Derivatives. II. Syntheses and Growth-inhibitory Activity against L-1210 Cells of 5-(4-Substituted-phenylthiomethyl)-6-carbamoyluracils

Uracil Derivatives. II. Syntheses and Growth-inhibitory Activity against L-1210 Cells of 5-(4-Substituted-phenylthiomethyl)-6-carbamoyluracils

5-(Substituted-thiomethyl)-6-carbamoyluracils (IIIa-f and VIa-c) were prepared in two steps from 5-chloromethyl-6-ethoxycarbonyluracil (I). Oxidation of IIIa-c gave the corresponding sulfones (IVa-c). The compounds thus prepared were examined for growth inhibition of L-1210 cells in vitro and some o...

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Veröffentlicht in:Chemical & pharmaceutical bulletin 1981/11/25, Vol.29(11), pp.3112-3117
Hauptverfasser: OKADA, JUTARO, NAKANO, KOICHI, MIYAKE, HIROSHI, YASUFUKU, SHOJI
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Antineoplastic Agents - chemical synthesis
Leukemia L1210 - drug therapy
Mice
P-388 cells
Uracil - analogs & derivatives
Uracil - chemical synthesis
Uracil - pharmacology
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Zusammenfassung:5-(Substituted-thiomethyl)-6-carbamoyluracils (IIIa-f and VIa-c) were prepared in two steps from 5-chloromethyl-6-ethoxycarbonyluracil (I). Oxidation of IIIa-c gave the corresponding sulfones (IVa-c). The compounds thus prepared were examined for growth inhibition of L-1210 cells in vitro and some of them exhibited high activity.
ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.29.3112