DEMETHYLATION OF ANSAMITOCINS AND RELATED COMPOUNDS

DEMETHYLATION OF ANSAMITOCINS AND RELATED COMPOUNDS

Ansamitocins were converted into 20-O-demethyl derivatives by bacteria. The structures of these products were elucidated from their physicochemical properties and from the chemical conversion to ansamitocins with diazomethane.

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Bibliographische Detailangaben
Veröffentlicht in:Journal of antibiotics 1981, Vol.34(12), pp.1587-1590
Hauptverfasser: IZAWA, MOTOWO, NAKAHAMA, KAZUO, KASAHARA, FUMIKO, ASAI, MITSUKO, KISHI, TOYOKAZU
Format: Artikel
Sprache:eng
Schlagworte:
Bacteria - metabolism
Chemical Phenomena
Chemistry
Dealkylation
Maytansine - analogs & derivatives
Maytansine - metabolism
Oxazines - metabolism
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Beschreibung
Zusammenfassung:Ansamitocins were converted into 20-O-demethyl derivatives by bacteria. The structures of these products were elucidated from their physicochemical properties and from the chemical conversion to ansamitocins with diazomethane.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.34.1587