Novel HLA-A and HLA-B alleles

Novel HLA-A and HLA-B alleles

: Nine novel HLA‐A and HLA‐B alleles are described: A*2609, A*6803, A*6806, B*1539, B*1540, B*2712, B*4103, B*5109, and B*5603. Most appear to have arisen by gene conversion events. B*5603 appears to have arisen by a reciprocal recombination event joining exon 2 of a B*55/*56 allele with exon 3 of a...

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Bibliographische Detailangaben
Veröffentlicht in:Tissue antigens 1998-07, Vol.52 (1), p.84-87
Hauptverfasser: Hurley, C.K., Steiner, N., Kosman, C., Mitton, W., Koester, R., Bei, M., Bush, J., McCormack, J., Hahn, A., Henson, V., Hoyer, R., Wade, J.A., Hartzman, R.J., Ng, J.
Format: Artikel
Sprache:eng
Schlagworte:
Alleles
Amino Acid Sequence
Base Sequence
HLA-A
HLA-A Antigens - genetics
HLA-B
HLA-B Antigens - genetics
Humans
Molecular Sequence Data
polymorphism
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Beschreibung
Zusammenfassung:: Nine novel HLA‐A and HLA‐B alleles are described: A*2609, A*6803, A*6806, B*1539, B*1540, B*2712, B*4103, B*5109, and B*5603. Most appear to have arisen by gene conversion events. B*5603 appears to have arisen by a reciprocal recombination event joining exon 2 of a B*55/*56 allele with exon 3 of a B*15 allele. Serologically, the antigen encoded by this allele types with broad B22‐ and Bw6‐specific alloantisera. Also unique, the antigen encoded by B*2712 does not react with B27‐spedfic alloantisera but does react with Bw6‐specifk alloantisera.
ISSN:0001-2815
1399-0039
DOI:10.1111/j.1399-0039.1998.tb03029.x