Effects of Inosiplex on Host Defense Against Infections

The effect of Inosiplex, an antiviral agent, on host defense against infection was studied. Inosiplex augmented, to the same extent Levamisole did, lymphocyte proliferation stimulated with phytohemagglutinin, concanavalin A or mixed lymphocyte culture, but not with lipopolysaccharide, suggesting that Inosiplex chiefly act on the T cells. Inosiplex increased antibody production either in in vitro or in vivo experimental system and displayed most prominent effect in secondary response. In contrast, Levamisole had no effect on secondary response, suggesting that Inosiplex and Levamisole had different mode of action. Inosiplex potentiated cell-mediated immunity, phagocytotic activity and immune interferon production, but showed no influence on cytolytic activity of killer T cells, natural killer cells or on antibody-dependent cell-mediated cytolysis.