Studies on Tenuazonic Acid Analogs. V. Syntheses and Antitumor Activities of Indane-1, 3-dione Derivatives

Thirty-two derivatives of indane-1, 3-dione were synthesized and screened for the growth inhibition activity on sarcoma 180 cells in vitro and the antitumor activity against solid tumor in vivo. Among them, one compound, 2-(α-anilinobenzylidene)-indane-1, 3-dione, was ineffective in vitro, whereas i...

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Veröffentlicht in:	YAKUGAKU ZASSHI 1981/10/25, Vol.101(10), pp.960-964
Hauptverfasser:	MATSUO, TOSHIYASU, TAKAGI, TAKASHI, SAITO, KIMITOSHI, YUKI, HIDETAKA, YAMAGUCHI, TATSUAKI
Format:	Artikel
Sprache:	eng ; jpn
Schlagworte:	Animals Antineoplastic Agents - chemical synthesis Antineoplastic Agents - pharmacology antitumor cytostatic activity Female indane-1, 3-dione Indans - chemical synthesis Indenes - chemical synthesis Mice sarcoma 180 Sarcoma 180 - pathology Structure-Activity Relationship tenuazonic acid
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creator	MATSUO, TOSHIYASU TAKAGI, TAKASHI SAITO, KIMITOSHI YUKI, HIDETAKA YAMAGUCHI, TATSUAKI
description	Thirty-two derivatives of indane-1, 3-dione were synthesized and screened for the growth inhibition activity on sarcoma 180 cells in vitro and the antitumor activity against solid tumor in vivo. Among them, one compound, 2-(α-anilinobenzylidene)-indane-1, 3-dione, was ineffective in vitro, whereas it was effective in vivo not only by intraperitoneal injection but also by oral administration.
doi_str_mv	10.1248/yakushi1947.101.10_960
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source	MEDLINE; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese; Alma/SFX Local Collection
subjects	Animals Antineoplastic Agents - chemical synthesis Antineoplastic Agents - pharmacology antitumor cytostatic activity Female indane-1, 3-dione Indans - chemical synthesis Indenes - chemical synthesis Mice sarcoma 180 Sarcoma 180 - pathology Structure-Activity Relationship tenuazonic acid
title	Studies on Tenuazonic Acid Analogs. V. Syntheses and Antitumor Activities of Indane-1, 3-dione Derivatives
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