Studies on Tenuazonic Acid Analogs. V. Syntheses and Antitumor Activities of Indane-1, 3-dione Derivatives

Thirty-two derivatives of indane-1, 3-dione were synthesized and screened for the growth inhibition activity on sarcoma 180 cells in vitro and the antitumor activity against solid tumor in vivo. Among them, one compound, 2-(α-anilinobenzylidene)-indane-1, 3-dione, was ineffective in vitro, whereas it was effective in vivo not only by intraperitoneal injection but also by oral administration.