In vivo immune stimulation by interferon during viral infection

In vivo immune stimulation by interferon during viral infection

Treatment of Rhesus monkeys with human leukocyte interferon prevents the development of skin lesions after intradermal infection with vaccinia virus. The treatment does not prevent the development of immunity to vaccinia. Inactivated vaccinia virus, which is non-immunogenic in untreated monkeys, ind...

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Veröffentlicht in:Antiviral research 1981-09, Vol.1 (3), p.179-183
Hauptverfasser: Schellekens, Huub, Weimar, Willem, de Reus, Arie, Bolhuis, Reinier L.H., Cantell, Kari
Format: Artikel
Sprache:eng
Schlagworte:
Adjuvants, Immunologic
Animals
Antibodies, Viral - analysis
immune system
interferon
Interferons - immunology
Macaca mulatta
Vaccinia - immunology
Vaccinia virus - growth & development
Vaccinia virus - immunology
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Zusammenfassung:Treatment of Rhesus monkeys with human leukocyte interferon prevents the development of skin lesions after intradermal infection with vaccinia virus. The treatment does not prevent the development of immunity to vaccinia. Inactivated vaccinia virus, which is non-immunogenic in untreated monkeys, induced immunity under interferon treatment, indicating that interferon had an immunestimulating effect.
ISSN:0166-3542
1872-9096
DOI:10.1016/0166-3542(81)90006-1