4-Hydroxybenzoic acid: a hypoglycemic constituent of aqueous extract of Pandanus odorus root

Hypoglycemic activity-guided fraction led to the isolation of the known compound, 4-hydroxybenzoic acid, from Pandanus odorus Ridl. (Thai name: Toei-hom, Pandanaceae). This compound showed a hypoglycemic effect in normal rats after the oral administration of 5 mg/kg. Additionally, the compound incre...

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Veröffentlicht in:	Journal of ethnopharmacology 1998-08, Vol.62 (1), p.79-84
Hauptverfasser:	Peungvicha, Penchom, Temsiririrkkul, Rungravi, Prasain, Jeevan Kurmar, Tezuka, Yasuhiro, Kadota, Shigetoshi, Thirawarapan, Suwan S, Watanabe, Hiroshi
Format:	Artikel
Sprache:	eng
Schlagworte:	4-Hydroxybenzoic acid Animals Biological and medical sciences General pharmacology hypoglycemic agents Hypoglycemic Agents - chemistry Hypoglycemic Agents - pharmacology Hypoglycemic effect Insulin - blood Liver Glycogen - metabolism Magnetic Resonance Spectroscopy Medical sciences Molecular Structure Pandanus odorus Parabens - chemistry Parabens - pharmacology Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plant Extracts - chemistry Plant Extracts - pharmacology Plants, Medicinal - chemistry Rats Rats, Wistar toei-hom
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Zusammenfassung:	Hypoglycemic activity-guided fraction led to the isolation of the known compound, 4-hydroxybenzoic acid, from Pandanus odorus Ridl. (Thai name: Toei-hom, Pandanaceae). This compound showed a hypoglycemic effect in normal rats after the oral administration of 5 mg/kg. Additionally, the compound increased serum insulin levels and liver glycogen content in normal rats.
ISSN:	0378-8741 1872-7573
DOI:	10.1016/S0378-8741(98)00061-0