THE STUDY OF THE COLONIC MOTILITY IN 3 PATIENTS WITH PROGRESSIVE SYSTEMIC SCLEROSIS (P. S. S.)

The gastrointestinal tract is one of the major system affecte a by P. S. S., but the functional investegations of the colon in P. S. S. are not so much. The purpose of this study was to investigate the alternations of the colonic motility that occur in patients with P. S. S.. The colonic manometric studies using the open tipped method were performed in 3 patients with P. S. S., at 3 portions of the colon, sigmoid, transverse and ascending colon, and were compared to normal subjects. The motility index (M.I.) was used as a parameter. At a basal time, M.I. was low titer as compare to normal subjects. The response of the colonic motility to neostigmin 0.5mg administration correlates with the duration and severity of the clinical disease. The abnormality of the colonic motility was to measure in patients with P. S. S. who had no colonic symptoms and normal findings on barium enema. The measurement of the colonic manometory may be useful for the diagnosis of the colonic severity in P. S. S.. But both at basal time and at neostigmin loading, the difference of the motility in each portions of the colon were unclear.