Comparison of metoprolol and carvedilol pharmacology and cardioprotection in rabbit ischemia and reperfusion model

Carvedilol, a selective α 1 and non-selective β-adrenoceptor antagonist and antioxidant, has been shown to provide significant cardiac protection in animal models of myocardial ischemia. To further explore the mechanisms contributing to carvedilol cardioprotection efficacy, the effects of carvedilol...

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Veröffentlicht in:European journal of pharmacology 1998-06, Vol.351 (3), p.341-350
Hauptverfasser: Feuerstein, Giora, Liu, Gao-Lin, Yue, Tian-Li, Cheng, H-Y, Hieble, J.Paul, Arch, Jonathan R.S, Ruffolo, Robert R, Ma, X.-L
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Sprache:eng
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Zusammenfassung:Carvedilol, a selective α 1 and non-selective β-adrenoceptor antagonist and antioxidant, has been shown to provide significant cardiac protection in animal models of myocardial ischemia. To further explore the mechanisms contributing to carvedilol cardioprotection efficacy, the effects of carvedilol on hemodynamic variables, infarct size and myeloperoxidase activity (an index of neutrophil accumulation) were compared with a β 1-selective adrenoceptor antagonist, metoprolol. Carvedilol (1 mg/kg) or metoprolol (1 mg/kg or 1 mg/kg+0.5 mg/kg 90 min later) was given intravenously 5 min before reperfusion. In vehicle-treated rabbits, ischemia (60 min) and reperfusion (180 min) resulted in significant increments in left ventricular end diastolic pressure, large infarcts (59±2.6% of area-at-risk) and marked increase in myeloperoxidase activity (0.59±0.09 U/100 mg tissue). Carvedilol treatment resulted in sustained reduction of pressure-rate-index and significantly smaller infarcts (22.0±2.5%, P
ISSN:0014-2999
1879-0712
DOI:10.1016/S0014-2999(98)00326-4