Fluostatins A and B, New Inhibitors of Dipeptidyl Peptidase III, Produced by Streptomyces sp. TA-3391: II. Structure Determination

In the course of our screening program for new inhibitors of dipeptidyl peptidase III (EC 3.4.14.4), we discovered fluostatins A and B from the culture broth of Streptomyces sp. TA-3391. The taxonomy of the producing strain, fermentation, isolation, physico-chemical properties and biological propert...

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Veröffentlicht in:	Journal of antibiotics 1998/06/25, Vol.51(6), pp.586-588
Hauptverfasser:	AKIYAMA, TETSUO, NAKAMURA, KAZUO T., TAKAHASHI, YOSHIKAZU, NAGANAWA, HIROSHI, MURAOKA, YASUHIKO, AOYAGI, TAKAAKI, TAKEUCHI, TOMIO
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics. Antiinfectious agents. Antiparasitic agents Antifungal agents Biological and medical sciences Crystallography, X-Ray Dipeptidyl-Peptidases and Tripeptidyl-Peptidases - antagonists & inhibitors Fluorenes - chemistry Magnetic Resonance Spectroscopy Mass Spectrometry Medical sciences Pharmacology. Drug treatments Protein Synthesis Inhibitors - chemistry Streptomyces Streptomyces - classification Streptomyces - metabolism
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Zusammenfassung:	In the course of our screening program for new inhibitors of dipeptidyl peptidase III (EC 3.4.14.4), we discovered fluostatins A and B from the culture broth of Streptomyces sp. TA-3391. The taxonomy of the producing strain, fermentation, isolation, physico-chemical properties and biological properties have been described in the preceding paper. Here we report on the structure determination of 1 and 2 on the basis of spectroscopic studies, chemical studies and X-ray crystallographic analysis.
ISSN:	0021-8820 1881-1469
DOI:	10.7164/antibiotics.51.586