Lethal effect of cis- but not trans-22-dehydrocholesterol on mouse fibroblast cells

Lethal effect of cis- but not trans-22-dehydrocholesterol on mouse fibroblast cells

cis- and trans-22-dehydrocholesterol were incorporated into the culture medium for mouse fibroblasts cells. Although neither isomer had an effect on sterol biosynthesis, the cis isomer inhibited cell growth and viability and increased Rb+ efflux from the cells. The trans isomer had no effect on grow...

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Veröffentlicht in:Lipids 1981-12, Vol.16 (12), p.943-945
Hauptverfasser: Kircher, H W, Rosenstein, F U, Kandutsch, A A
Format: Artikel
Sprache:eng
Schlagworte:
Cell Division - drug effects
Cell Survival - drug effects
Cells, Cultured
Cholestadienols - pharmacology
Cholesterol - pharmacology
Dehydrocholesterols - pharmacology
Fibroblasts - cytology
Fibroblasts - metabolism
Hydroxycholesterols - pharmacology
Rubidium - metabolism
Stereoisomerism
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Zusammenfassung:cis- and trans-22-dehydrocholesterol were incorporated into the culture medium for mouse fibroblasts cells. Although neither isomer had an effect on sterol biosynthesis, the cis isomer inhibited cell growth and viability and increased Rb+ efflux from the cells. The trans isomer had no effect on growth and could replace exogenous cholesterol for growth of cells for which sterol biosynthesis was blocked by 25-hydroxycholesterol.
ISSN:0024-4201
1558-9307
DOI:10.1007/BF02535004