Multiple-system atrophy: a new α-synuclein disease?

The presence of abundant alpha-synuclein immunoreactivity suggests that the abnormalities in gene expression or protein structure in alpha-synuclein or associated proteins may contribute to the pathogenesis of multiple-system atrophy, thereby linking it with other diseases associated with abnormalit...

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Veröffentlicht in:	The Lancet (British edition) 1998-08, Vol.352 (9127), p.547-548
Hauptverfasser:	Gai, WP, Power, JHT, Blumbergs, PC, Blessing, WW
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Synuclein Biological and medical sciences Brain Stem - pathology Coloring Agents Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Dementia - pathology Genetics Humans Inclusion Bodies - ultrastructure Lewy Bodies - pathology Medical sciences Motor Neuron Disease - pathology Multiple System Atrophy - pathology Nerve Tissue Proteins - analysis Neurites - ultrastructure Neuroglia - pathology Neurological disorders Neurology Neurons - pathology Parkinson Disease - pathology Pathology Phosphoproteins - analysis Proteins Silver Synucleins
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Beschreibung
Zusammenfassung:	The presence of abundant alpha-synuclein immunoreactivity suggests that the abnormalities in gene expression or protein structure in alpha-synuclein or associated proteins may contribute to the pathogenesis of multiple-system atrophy, thereby linking it with other diseases associated with abnormalities in alpha-synuclein.
ISSN:	0140-6736 1474-547X
DOI:	10.1016/S0140-6736(05)79256-4