The effects of arachidonic acid on aqueous humor dynamics of the isolated arterially perfused cat eye
Arterial perfusion of isolated cat eyes with arachidonic acid (AA) increases the inflow of aqueous humor (AH), elevates the intraocular pressure (IOP) and constricts the pupil. The effect may be due to an observed vasoconstrictive action of AA on the blood vessels of the anterior segment of the eye....
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| Veröffentlicht in: | Prostaglandins and medicine 1981-11, Vol.7 (5), p.403-409 |
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| container_end_page | 409 |
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| container_title | Prostaglandins and medicine |
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| creator | van Alphen, G.W.H.M. Macri, Frank J. |
| description | Arterial perfusion of isolated cat eyes with arachidonic acid (AA) increases the inflow of aqueous humor (AH), elevates the intraocular pressure (IOP) and constricts the pupil. The effect may be due to an observed vasoconstrictive action of AA on the blood vessels of the anterior segment of the eye. Indomethacin completely prevents the increase in AH formation and the constriction of the pupil but does not block the rise in IOP. |
| doi_str_mv | 10.1016/0161-4630(81)90029-X |
| format | Article |
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The effect may be due to an observed vasoconstrictive action of AA on the blood vessels of the anterior segment of the eye. 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Indomethacin completely prevents the increase in AH formation and the constriction of the pupil but does not block the rise in IOP.</description><subject>Animals</subject><subject>Aqueous Humor - drug effects</subject><subject>Aqueous Humor - metabolism</subject><subject>Arachidonic Acid</subject><subject>Arachidonic Acids - pharmacology</subject><subject>Cats</subject><subject>Epinephrine - pharmacology</subject><subject>Female</subject><subject>Indomethacin - pharmacology</subject><subject>Intraocular Pressure - drug effects</subject><subject>Male</subject><subject>Perfusion</subject><subject>Pupil - drug effects</subject><subject>Tranylcypromine - pharmacology</subject><subject>Vasoconstriction - drug effects</subject><issn>0161-4630</issn><issn>1878-0636</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1981</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtKxDAUhoMoOl7eQCEr0UU1lzZJN4KINxDcKMwupMkpE2mbMWmFeXszF1y6OARyvv8k50PonJIbSqi4zUWLUnBypeh1TQiri_kemlElVUEEF_to9occoeOUvjKjSlEdokMha1UpOUPwsQAMbQt2TDi02ERjF96FwVtsrHc4DNh8TxCmhBdTHyJ2q8H03m7oMYd9Cp0ZweXoCNGbrlvhJcR2SvnOmhHDCk7RQWu6BGe78wR9Pj1-PLwUb-_Prw_3b4XllRyLllFrG0EcgDSCqUpWgjkOklFSNZY0hjWQi4AE6WwpSsZl3YKpoWKMN_wEXW7nLmPIn06j7n2y0HVmWG-gJVdlVXKSwXIL2hhSitDqZfS9iStNiV7b1Wt1eq1OK6o3dvU8xy5286emB_cX2unM_bttH_KSPx6iTtbDYMH5mA1rF_z_D_wCxxOKuw</recordid><startdate>198111</startdate><enddate>198111</enddate><creator>van Alphen, G.W.H.M.</creator><creator>Macri, Frank J.</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198111</creationdate><title>The effects of arachidonic acid on aqueous humor dynamics of the isolated arterially perfused cat eye</title><author>van Alphen, G.W.H.M. ; Macri, Frank J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-f21ccb60dee7a62857562d3e72105bc0ba2bea2b0e7e7dc4642379fea9e5223b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1981</creationdate><topic>Animals</topic><topic>Aqueous Humor - drug effects</topic><topic>Aqueous Humor - metabolism</topic><topic>Arachidonic Acid</topic><topic>Arachidonic Acids - pharmacology</topic><topic>Cats</topic><topic>Epinephrine - pharmacology</topic><topic>Female</topic><topic>Indomethacin - pharmacology</topic><topic>Intraocular Pressure - drug effects</topic><topic>Male</topic><topic>Perfusion</topic><topic>Pupil - drug effects</topic><topic>Tranylcypromine - pharmacology</topic><topic>Vasoconstriction - drug effects</topic><toplevel>online_resources</toplevel><creatorcontrib>van Alphen, G.W.H.M.</creatorcontrib><creatorcontrib>Macri, Frank J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Prostaglandins and medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>van Alphen, G.W.H.M.</au><au>Macri, Frank J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effects of arachidonic acid on aqueous humor dynamics of the isolated arterially perfused cat eye</atitle><jtitle>Prostaglandins and medicine</jtitle><addtitle>Prostaglandins Med</addtitle><date>1981-11</date><risdate>1981</risdate><volume>7</volume><issue>5</issue><spage>403</spage><epage>409</epage><pages>403-409</pages><issn>0161-4630</issn><eissn>1878-0636</eissn><abstract>Arterial perfusion of isolated cat eyes with arachidonic acid (AA) increases the inflow of aqueous humor (AH), elevates the intraocular pressure (IOP) and constricts the pupil. 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| identifier | ISSN: 0161-4630 |
| ispartof | Prostaglandins and medicine, 1981-11, Vol.7 (5), p.403-409 |
| issn | 0161-4630 1878-0636 |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Animals Aqueous Humor - drug effects Aqueous Humor - metabolism Arachidonic Acid Arachidonic Acids - pharmacology Cats Epinephrine - pharmacology Female Indomethacin - pharmacology Intraocular Pressure - drug effects Male Perfusion Pupil - drug effects Tranylcypromine - pharmacology Vasoconstriction - drug effects |
| title | The effects of arachidonic acid on aqueous humor dynamics of the isolated arterially perfused cat eye |
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