The effects of arachidonic acid on aqueous humor dynamics of the isolated arterially perfused cat eye

Arterial perfusion of isolated cat eyes with arachidonic acid (AA) increases the inflow of aqueous humor (AH), elevates the intraocular pressure (IOP) and constricts the pupil. The effect may be due to an observed vasoconstrictive action of AA on the blood vessels of the anterior segment of the eye....

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Veröffentlicht in:	Prostaglandins and medicine 1981-11, Vol.7 (5), p.403-409
Hauptverfasser:	van Alphen, G.W.H.M., Macri, Frank J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aqueous Humor - drug effects Aqueous Humor - metabolism Arachidonic Acid Arachidonic Acids - pharmacology Cats Epinephrine - pharmacology Female Indomethacin - pharmacology Intraocular Pressure - drug effects Male Perfusion Pupil - drug effects Tranylcypromine - pharmacology Vasoconstriction - drug effects
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Zusammenfassung:	Arterial perfusion of isolated cat eyes with arachidonic acid (AA) increases the inflow of aqueous humor (AH), elevates the intraocular pressure (IOP) and constricts the pupil. The effect may be due to an observed vasoconstrictive action of AA on the blood vessels of the anterior segment of the eye. Indomethacin completely prevents the increase in AH formation and the constriction of the pupil but does not block the rise in IOP.
ISSN:	0161-4630 1878-0636
DOI:	10.1016/0161-4630(81)90029-X