STUDIES ON SF-1902 A2-A5, MINOR COMPONENTS OF SF-1902 (GLOBOMYCIN)

STUDIES ON SF-1902 A2-A5, MINOR COMPONENTS OF SF-1902 (GLOBOMYCIN)

Four members of globomycin, SF-1902 A2, A3, A4a and A4b were newly isolated from the culture of Streptomyces hygroscopicus SF-1902. These minor components shared four amino acids in common and the fifth was either valine or allo-isoleucine. The fatty acid moiety varied from 3-hydroxy-2-methylheptano...

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Veröffentlicht in:Journal of antibiotics 1981, Vol.34(11), pp.1416-1423
Hauptverfasser: OMOTO, SHOJI, OGINO, HIROKO, INOUYE, SHIGEHARU
Format: Artikel
Sprache:eng
Schlagworte:
Acetylation
Amino Acids - analysis
Anti-Bacterial Agents
Chemical Phenomena
Chemistry
Chemistry, Physical
Fatty Acids - analysis
Fermentation
Hydroxylation
Mass Spectrometry
Peptide Biosynthesis
Peptides - analysis
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Zusammenfassung:Four members of globomycin, SF-1902 A2, A3, A4a and A4b were newly isolated from the culture of Streptomyces hygroscopicus SF-1902. These minor components shared four amino acids in common and the fifth was either valine or allo-isoleucine. The fatty acid moiety varied from 3-hydroxy-2-methylheptanoic acid in A2 to 3-hydroxy-2-methylundecanoic acids in A4b. The length of alkyl chain greatly affected the antibacterial activity, and maximum activity was shown by the homologue (A5) possessing the longest alkyl chain.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.34.1416