The lactate metabolism of the oral bacterium Veillonella from human saliva

Lactate is metabolized by Veillonella via the methylmalonyl-coenzyme A (CoA) pathway to propionate and, by further pathways, to acetate. Whereas pyruvate and oxaloacetate are metabolized via the pyruvate-formate lyase reaction, lactate acts as a donor of hydrogen allowing the reduction of oxaloaceta...

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Veröffentlicht in:Archives of oral biology 1981, Vol.26 (8), p.657-661
Hauptverfasser: Distler, W., Kröncke, A.
Format: Artikel
Sprache:eng
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Zusammenfassung:Lactate is metabolized by Veillonella via the methylmalonyl-coenzyme A (CoA) pathway to propionate and, by further pathways, to acetate. Whereas pyruvate and oxaloacetate are metabolized via the pyruvate-formate lyase reaction, lactate acts as a donor of hydrogen allowing the reduction of oxaloacetate to malate in the methylmalonyl-CoA pathway. Succinate, believed to be an intermediate in lactate metabolism of Veillonellae is readily decarboxylated to propionate by these organisms, but a severe, progressive substrate inhibition occurs at concentrations above 12–16 mmol/l.
ISSN:0003-9969
1879-1506
DOI:10.1016/0003-9969(81)90162-X