The lactate metabolism of the oral bacterium Veillonella from human saliva
Lactate is metabolized by Veillonella via the methylmalonyl-coenzyme A (CoA) pathway to propionate and, by further pathways, to acetate. Whereas pyruvate and oxaloacetate are metabolized via the pyruvate-formate lyase reaction, lactate acts as a donor of hydrogen allowing the reduction of oxaloaceta...
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Veröffentlicht in: | Archives of oral biology 1981, Vol.26 (8), p.657-661 |
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Hauptverfasser: | , |
Format: | Artikel |
Sprache: | eng |
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Online-Zugang: | Volltext |
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Zusammenfassung: | Lactate is metabolized by
Veillonella via the methylmalonyl-coenzyme A (CoA) pathway to propionate and, by further pathways, to acetate. Whereas pyruvate and oxaloacetate are metabolized via the pyruvate-formate lyase reaction, lactate acts as a donor of hydrogen allowing the reduction of oxaloacetate to malate in the methylmalonyl-CoA pathway. Succinate, believed to be an intermediate in lactate metabolism of
Veillonellae is readily decarboxylated to propionate by these organisms, but a severe, progressive substrate inhibition occurs at concentrations above 12–16 mmol/l. |
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ISSN: | 0003-9969 1879-1506 |
DOI: | 10.1016/0003-9969(81)90162-X |