Penta-acetyl-gitoxin: the prototype of a prodrug in the cardiac glycoside series
Penta-acetyl-gitoxin is a suitable prodrug of gitoxin since it shows--side-effect latentiation, due to its inactive application form;--bioavailability, due to its improved solubility and thus good enteral absorption and--bioactivation, due to rapid de-acetylation in the body after absorption.
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| Veröffentlicht in: | Pharmazie 1977-11, Vol.32 (11), p.665-667 |
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| container_end_page | 667 |
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| container_issue | 11 |
| container_start_page | 665 |
| container_title | Pharmazie |
| container_volume | 32 |
| creator | Megges, R Portius, H J Repke, K R |
| description | Penta-acetyl-gitoxin is a suitable prodrug of gitoxin since it shows--side-effect latentiation, due to its inactive application form;--bioavailability, due to its improved solubility and thus good enteral absorption and--bioactivation, due to rapid de-acetylation in the body after absorption. |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 0031-7144 |
| ispartof | Pharmazie, 1977-11, Vol.32 (11), p.665-667 |
| issn | 0031-7144 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_73834587 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek |
| subjects | Animals Biological Availability Chemistry, Pharmaceutical Digitalis Glycosides - metabolism Digitalis Glycosides - pharmacology Digitoxin - metabolism Digitoxin - pharmacology Guinea Pigs Humans In Vitro Techniques Muscle Tonus - drug effects Rats |
| title | Penta-acetyl-gitoxin: the prototype of a prodrug in the cardiac glycoside series |
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