Penta-acetyl-gitoxin: the prototype of a prodrug in the cardiac glycoside series

Penta-acetyl-gitoxin is a suitable prodrug of gitoxin since it shows--side-effect latentiation, due to its inactive application form;--bioavailability, due to its improved solubility and thus good enteral absorption and--bioactivation, due to rapid de-acetylation in the body after absorption.

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Pharmazie 1977-11, Vol.32 (11), p.665-667
Hauptverfasser:	Megges, R, Portius, H J, Repke, K R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Availability Chemistry, Pharmaceutical Digitalis Glycosides - metabolism Digitalis Glycosides - pharmacology Digitoxin - metabolism Digitoxin - pharmacology Guinea Pigs Humans In Vitro Techniques Muscle Tonus - drug effects Rats
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Penta-acetyl-gitoxin is a suitable prodrug of gitoxin since it shows--side-effect latentiation, due to its inactive application form;--bioavailability, due to its improved solubility and thus good enteral absorption and--bioactivation, due to rapid de-acetylation in the body after absorption.
ISSN:	0031-7144