Effect of Dehydration on the Pharmacokinetics of Oxytetracycline Hydrochloride Administered Intravenously in Goats ( Capra hircus)
1. The effects of various levels of dehydration induced by water deprivation were studied in six Nubian goats on the pharmacokinetics of oxytetracycline after intravenous administration (5 mg/kg). 2. In goats that had lost an average of 7.6% body weight after 2 days of water deprivation, the elimina...
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| Veröffentlicht in: | General pharmacology 1998-09, Vol.31 (3), p.455-458 |
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| container_title | General pharmacology |
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| creator | Elsheikh, H.A. Intisar, A.M.Osman Eltayeb, I.B. Abdullah, A.Salam |
| description | 1.
The effects of various levels of dehydration induced by water deprivation were studied in six Nubian goats on the pharmacokinetics of oxytetracycline after intravenous administration (5 mg/kg).
2.
In goats that had lost an average of 7.6% body weight after 2 days of water deprivation, the elimination rate constant of the drug was significantly decreased (
P |
| doi_str_mv | 10.1016/S0306-3623(98)00013-5 |
| format | Article |
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The effects of various levels of dehydration induced by water deprivation were studied in six Nubian goats on the pharmacokinetics of oxytetracycline after intravenous administration (5 mg/kg).
2.
In goats that had lost an average of 7.6% body weight after 2 days of water deprivation, the elimination rate constant of the drug was significantly decreased (
P<0.01) and the total body clearance was significantly slower (
P<0.001). No statistically significant changes were observed in the pharmacokinetic parameters describing the distribution of the drug at this dehydration level.
3.
Water deprivation for 3 or 4 days resulted in a level of dehydration at which the goats lost an average of 10.3% or 12.7% of their body weight, respectively; significant changes were observed in the pharmacokinetic distribution and elimination parameters of oxytetracycline. The volume of distribution at steady state was significantly decreased (
P<0.01). Significantly slower total body clearance (
P<0.001) and subsequent prolongation of the elimination half-life were found at these dehydration levels.
4.
The alterations caused by dehydration on the disposition kinetics of the drug should be considered for better definition of dosage regimens for sick, dehydrated animals.</description><identifier>ISSN: 0306-3623</identifier><identifier>EISSN: 1879-0011</identifier><identifier>DOI: 10.1016/S0306-3623(98)00013-5</identifier><identifier>PMID: 9703219</identifier><identifier>CODEN: GEPHDP</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Animals ; Anti-Bacterial Agents - blood ; Anti-Bacterial Agents - pharmacokinetics ; Antibacterial agents ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Biological and medical sciences ; Body Water - metabolism ; Dehydration ; Dehydration - metabolism ; goat ; Goats ; Injections, Intravenous ; Male ; Medical sciences ; Metabolic Clearance Rate - drug effects ; oxytetracycline ; Oxytetracycline - blood ; Oxytetracycline - pharmacokinetics ; pharmacokinetics ; Pharmacology. Drug treatments ; Water Deprivation</subject><ispartof>General pharmacology, 1998-09, Vol.31 (3), p.455-458</ispartof><rights>1998 Elsevier Science Inc.</rights><rights>1998 INIST-CNRS</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c436t-ec44103a2f68e3a026e505381daac32b3d8fa63bda2f1690619b76c384e222a33</citedby><cites>FETCH-LOGICAL-c436t-ec44103a2f68e3a026e505381daac32b3d8fa63bda2f1690619b76c384e222a33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,782,786,27931,27932</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2404068$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9703219$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Elsheikh, H.A.</creatorcontrib><creatorcontrib>Intisar, A.M.Osman</creatorcontrib><creatorcontrib>Eltayeb, I.B.</creatorcontrib><creatorcontrib>Abdullah, A.Salam</creatorcontrib><title>Effect of Dehydration on the Pharmacokinetics of Oxytetracycline Hydrochloride Administered Intravenously in Goats ( Capra hircus)</title><title>General pharmacology</title><addtitle>Gen Pharmacol</addtitle><description>1.
The effects of various levels of dehydration induced by water deprivation were studied in six Nubian goats on the pharmacokinetics of oxytetracycline after intravenous administration (5 mg/kg).
2.
In goats that had lost an average of 7.6% body weight after 2 days of water deprivation, the elimination rate constant of the drug was significantly decreased (
P<0.01) and the total body clearance was significantly slower (
P<0.001). No statistically significant changes were observed in the pharmacokinetic parameters describing the distribution of the drug at this dehydration level.
3.
Water deprivation for 3 or 4 days resulted in a level of dehydration at which the goats lost an average of 10.3% or 12.7% of their body weight, respectively; significant changes were observed in the pharmacokinetic distribution and elimination parameters of oxytetracycline. The volume of distribution at steady state was significantly decreased (
P<0.01). Significantly slower total body clearance (
P<0.001) and subsequent prolongation of the elimination half-life were found at these dehydration levels.
4.
The alterations caused by dehydration on the disposition kinetics of the drug should be considered for better definition of dosage regimens for sick, dehydrated animals.</description><subject>Animals</subject><subject>Anti-Bacterial Agents - blood</subject><subject>Anti-Bacterial Agents - pharmacokinetics</subject><subject>Antibacterial agents</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Biological and medical sciences</subject><subject>Body Water - metabolism</subject><subject>Dehydration</subject><subject>Dehydration - metabolism</subject><subject>goat</subject><subject>Goats</subject><subject>Injections, Intravenous</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metabolic Clearance Rate - drug effects</subject><subject>oxytetracycline</subject><subject>Oxytetracycline - blood</subject><subject>Oxytetracycline - pharmacokinetics</subject><subject>pharmacokinetics</subject><subject>Pharmacology. Drug treatments</subject><subject>Water Deprivation</subject><issn>0306-3623</issn><issn>1879-0011</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkV1rFDEUhoModVv9CYVciLQXo_mYyWaupKy1LRQqqNfhbHKGic5M1iRbOrf-8ma7y94KgZCc5z05PCHknLNPnHH1-QeTTFVSCXnR6kvGGJdV84osuF62VTnx12RxRN6S05R-F0g0QpyQk3bJpODtgvy77jq0mYaOfsV-dhGyDxMtK_dIv_cQR7Dhj58we5t22MPTnDFHsLMdyjW9LaFg-yFE75BeudFPPmWM6OjdVLhHnMI2DTP1E70JkBO9oCvYRKC9j3abLt-RNx0MCd8f9jPy69v1z9Vtdf9wc7e6uq9sLVWu0NY1ZxJEpzRKYEJhwxqpuQOwUqyl0x0ouXaF4KplirfrpbJS1yiEACnPyMd9300Mf7eYshl9sjgMMGGZ0CylloJpUcBmD9oYUorYmU30I8TZcGZ27s2Le7MTa1ptXtybpuTODw9s1yO6Y-ogu9Q_HOqQLAxdhMn6dMREzWqmdMG-7DEsMh49RpOsx8mi87F8lXHB_2eQZ5hmobA</recordid><startdate>19980901</startdate><enddate>19980901</enddate><creator>Elsheikh, H.A.</creator><creator>Intisar, A.M.Osman</creator><creator>Eltayeb, I.B.</creator><creator>Abdullah, A.Salam</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19980901</creationdate><title>Effect of Dehydration on the Pharmacokinetics of Oxytetracycline Hydrochloride Administered Intravenously in Goats ( Capra hircus)</title><author>Elsheikh, H.A. ; Intisar, A.M.Osman ; Eltayeb, I.B. ; Abdullah, A.Salam</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c436t-ec44103a2f68e3a026e505381daac32b3d8fa63bda2f1690619b76c384e222a33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Animals</topic><topic>Anti-Bacterial Agents - blood</topic><topic>Anti-Bacterial Agents - pharmacokinetics</topic><topic>Antibacterial agents</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Biological and medical sciences</topic><topic>Body Water - metabolism</topic><topic>Dehydration</topic><topic>Dehydration - metabolism</topic><topic>goat</topic><topic>Goats</topic><topic>Injections, Intravenous</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metabolic Clearance Rate - drug effects</topic><topic>oxytetracycline</topic><topic>Oxytetracycline - blood</topic><topic>Oxytetracycline - pharmacokinetics</topic><topic>pharmacokinetics</topic><topic>Pharmacology. Drug treatments</topic><topic>Water Deprivation</topic><toplevel>online_resources</toplevel><creatorcontrib>Elsheikh, H.A.</creatorcontrib><creatorcontrib>Intisar, A.M.Osman</creatorcontrib><creatorcontrib>Eltayeb, I.B.</creatorcontrib><creatorcontrib>Abdullah, A.Salam</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>General pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Elsheikh, H.A.</au><au>Intisar, A.M.Osman</au><au>Eltayeb, I.B.</au><au>Abdullah, A.Salam</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Dehydration on the Pharmacokinetics of Oxytetracycline Hydrochloride Administered Intravenously in Goats ( Capra hircus)</atitle><jtitle>General pharmacology</jtitle><addtitle>Gen Pharmacol</addtitle><date>1998-09-01</date><risdate>1998</risdate><volume>31</volume><issue>3</issue><spage>455</spage><epage>458</epage><pages>455-458</pages><issn>0306-3623</issn><eissn>1879-0011</eissn><coden>GEPHDP</coden><abstract>1.
The effects of various levels of dehydration induced by water deprivation were studied in six Nubian goats on the pharmacokinetics of oxytetracycline after intravenous administration (5 mg/kg).
2.
In goats that had lost an average of 7.6% body weight after 2 days of water deprivation, the elimination rate constant of the drug was significantly decreased (
P<0.01) and the total body clearance was significantly slower (
P<0.001). No statistically significant changes were observed in the pharmacokinetic parameters describing the distribution of the drug at this dehydration level.
3.
Water deprivation for 3 or 4 days resulted in a level of dehydration at which the goats lost an average of 10.3% or 12.7% of their body weight, respectively; significant changes were observed in the pharmacokinetic distribution and elimination parameters of oxytetracycline. The volume of distribution at steady state was significantly decreased (
P<0.01). Significantly slower total body clearance (
P<0.001) and subsequent prolongation of the elimination half-life were found at these dehydration levels.
4.
The alterations caused by dehydration on the disposition kinetics of the drug should be considered for better definition of dosage regimens for sick, dehydrated animals.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>9703219</pmid><doi>10.1016/S0306-3623(98)00013-5</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | General pharmacology, 1998-09, Vol.31 (3), p.455-458 |
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| language | eng |
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| subjects | Animals Anti-Bacterial Agents - blood Anti-Bacterial Agents - pharmacokinetics Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Body Water - metabolism Dehydration Dehydration - metabolism goat Goats Injections, Intravenous Male Medical sciences Metabolic Clearance Rate - drug effects oxytetracycline Oxytetracycline - blood Oxytetracycline - pharmacokinetics pharmacokinetics Pharmacology. Drug treatments Water Deprivation |
| title | Effect of Dehydration on the Pharmacokinetics of Oxytetracycline Hydrochloride Administered Intravenously in Goats ( Capra hircus) |
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