Effect of Dehydration on the Pharmacokinetics of Oxytetracycline Hydrochloride Administered Intravenously in Goats ( Capra hircus)

1. The effects of various levels of dehydration induced by water deprivation were studied in six Nubian goats on the pharmacokinetics of oxytetracycline after intravenous administration (5 mg/kg). 2. In goats that had lost an average of 7.6% body weight after 2 days of water deprivation, the elimina...

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Veröffentlicht in:	General pharmacology 1998-09, Vol.31 (3), p.455-458
Hauptverfasser:	Elsheikh, H.A., Intisar, A.M.Osman, Eltayeb, I.B., Abdullah, A.Salam
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents - blood Anti-Bacterial Agents - pharmacokinetics Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Body Water - metabolism Dehydration Dehydration - metabolism goat Goats Injections, Intravenous Male Medical sciences Metabolic Clearance Rate - drug effects oxytetracycline Oxytetracycline - blood Oxytetracycline - pharmacokinetics pharmacokinetics Pharmacology. Drug treatments Water Deprivation
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Zusammenfassung:	1. The effects of various levels of dehydration induced by water deprivation were studied in six Nubian goats on the pharmacokinetics of oxytetracycline after intravenous administration (5 mg/kg). 2. In goats that had lost an average of 7.6% body weight after 2 days of water deprivation, the elimination rate constant of the drug was significantly decreased ( P
ISSN:	0306-3623 1879-0011
DOI:	10.1016/S0306-3623(98)00013-5