Simulation package for multiple intravenous infusions of two compartment pharmacokinetic drugs

A program is presented to simulate the blood concentrations of two compartment pharmacokinetic drugs following multiple or intermittent constant rate intravenous infusions. The package requires the data input of some two compartment parameters, the rates and lengths of the infusions, and provides blood concentration-time predictions utilizing the principle of superposition. A unique feature of the package is the graphical plotting option, which displays the entire simulation all at once. The package was developed on a 48 000 byte Radio Shack TRS-80 microcomputer ∗ ∗ Radio Shack, Division Tandy Corp., Forth Worth, Texas (U.S.A.). . The interpreter used was Radio Shack TRS-80 Level II Basic ∗ . This program is also compatible with TRS-80 Level III Basic ∗∗ ∗∗ A G2 Product from GRT, copyright 1979 by Microsoft. . Approximately 5300 bytes of memory are occupied by the program with another 500–1500 bytes being necessary for data and results.