Effector Cell Sensitivity to Sugar Moieties. I. Inhibition of Human Natural Killer Cell Activity by Monosaccharides

Effector Cell Sensitivity to Sugar Moieties. I. Inhibition of Human Natural Killer Cell Activity by Monosaccharides

Human natural killer (NK) cells recognize multiple target antigens. The ligands (antigens) involved in the effector-target cell interaction have not been extensively identified. In the present study, assays of NK activity in the presence of a panel of monosaccharides demonstrated inhibition of cytol...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Immunobiology (1979) 1981, Vol.160 (2), p.248-258
Hauptverfasser: Ades, E.W., Hinson, Ann, Decker, Janet M.
Format: Artikel
Sprache:eng
Schlagworte:
Antibody-Dependent Cell Cytotoxicity - drug effects
Antigens - immunology
Humans
Killer Cells, Natural - drug effects
Killer Cells, Natural - immunology
Monosaccharides - immunology
Monosaccharides - pharmacology
Receptors, Antigen - immunology
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Human natural killer (NK) cells recognize multiple target antigens. The ligands (antigens) involved in the effector-target cell interaction have not been extensively identified. In the present study, assays of NK activity in the presence of a panel of monosaccharides demonstrated inhibition of cytolysis in a dose-response fashion. We propose that NK cell activity involves the recognition of carbohydrate structures on target cells via receptors on the effector cell surface.
ISSN:0171-2985
1878-3279
DOI:10.1016/S0171-2985(81)80052-6