The Efficacy of 4-Amino-6-Trichloroethenyl-1,3-Benzenedisulphonamide Against Liver Fluke in Sheep and Cattle

Extensive chemical modification and biological testing of benzenesulphonamides resulted in the selection of 4-amino-6-trichloroethenyl-1,3-benzenedisulphonamide as the most promising fasciolicide in this series. Dosages of 10 and 15mg/kg were 97 and 92% effective against immature liver flukes in cal...

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Veröffentlicht in:	British veterinary journal 1977-03, Vol.133 (2), p.211-214
Hauptverfasser:	Ostlind, D.A., Campbell, W.C., Riek, R.F., Baylis, P., Cifelli, S., Hartman, R.K., Lang, R.K., Butler, R.W., Mrozik, H., Bochis, R.J., Eskola, P., Matzuk, A., Waksmunski, F.S., Olen, L.E., Schwartzkopf, G., Grodski, A., Linn, B.O., Lusi, A., Wu, M.T., Shunk, C.H., Peterson, L.H., Milkowski, J.D., Hoff, D.R., Kulsa, P., Harmon, R.E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antiplatyhelmintic Agents - therapeutic use Cattle Cattle Diseases - drug therapy Fascioliasis - drug therapy Fascioliasis - veterinary Female Male Sheep Sheep Diseases - drug therapy Sulfanilamides - therapeutic use Trichloroethylene - analogs & derivatives Trichloroethylene - therapeutic use
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Beschreibung
Zusammenfassung:	Extensive chemical modification and biological testing of benzenesulphonamides resulted in the selection of 4-amino-6-trichloroethenyl-1,3-benzenedisulphonamide as the most promising fasciolicide in this series. Dosages of 10 and 15mg/kg were 97 and 92% effective against immature liver flukes in calves and sheep respectively. Mature flukes in both sheep and cattle were removed by a single dose of 3·75mg/kg.
ISSN:	0007-1935
DOI:	10.1016/S0007-1935(17)34144-1