In vivo high-affinity uptake and axonal transport of D-[2, 3- 3H]aspartate in excitatory neurons

d-[2,3- 3H]aspartate ([ 3H] d-Asp) at μM concentrations in Krebs' solution was infused intracerebrally in rats, mice and hamsters. Neuropil sites in the hippocampal formation, septum and neostriatum, known to receive excitatory nerve inputs with glutamate and aspartate as putative transmitters,...

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Veröffentlicht in:	Brain research 1981-12, Vol.230 (1), p.427-433
Hauptverfasser:	Strom-Mathisen, J., Wold, J.E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals aspartate Aspartic Acid - metabolism Autoradiography Axonal Transport Brain - metabolism Caudate Nucleus - metabolism Cerebral Cortex - metabolism Cerebral Ventricles - metabolism cortex Cricetinae excitatory neurons glutamate Glutamates - metabolism Glutamic Acid high-affinity uptake hippocampus Hippocampus - metabolism Mesocricetus Mice Neurons - metabolism Putamen - metabolism Rats Rats, Inbred Strains septum Septum Pellucidum - metabolism striatum Synaptic Transmission
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Zusammenfassung:	d-[2,3- 3H]aspartate ([ 3H] d-Asp) at μM concentrations in Krebs' solution was infused intracerebrally in rats, mice and hamsters. Neuropil sites in the hippocampal formation, septum and neostriatum, known to receive excitatory nerve inputs with glutamate and aspartate as putative transmitters, showed strong autoradiographic labeling after intraventricular infusions. There was evidence for retrograde axonal transport to pyramidal cell bodies in hippocampus CA3 and neocortex. Infusions into the hilus fasciae dentatae led to anterograde axonal transport of [ 3H] d-Asp in the mossy fibers.
ISSN:	0006-8993 1872-6240
DOI:	10.1016/0006-8993(81)90428-5