Gas-liquid chromatography and mass spectrometry of methylated and acetylated methyl glycosides. Application to the structural analysis of glycoprotein glycans

The mass spectra of 52 partially methylated and acetylated methyl glycosides of galactose, mannose, glucose, and N-acetylglucosamine have been determined. Each derivative was identified on the basis of its gas-liquid chromatography retention time and mass spectra. The analysis of methyl ethers obtai...

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Veröffentlicht in:	Analytical biochemistry 1981-09, Vol.116 (2), p.489-502
Hauptverfasser:	Fournet, Bernard, Strecker, Gérard, Leroy, Yves, Montreuil, Jean
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Acetylglucosamine - analogs & derivatives Chemical Phenomena Chemistry Galactose Gas Chromatography-Mass Spectrometry - methods Glucose Mannose Methylation Methylglucosides Methylglycosides Orosomucoid - analysis Sialoglycoproteins
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Beschreibung
Zusammenfassung:	The mass spectra of 52 partially methylated and acetylated methyl glycosides of galactose, mannose, glucose, and N-acetylglucosamine have been determined. Each derivative was identified on the basis of its gas-liquid chromatography retention time and mass spectra. The analysis of methyl ethers obtained by methanolysis of fully methylated glycans of α1-acid glycoprotein is described as an application of the method.
ISSN:	0003-2697 1096-0309
DOI:	10.1016/0003-2697(81)90393-6