On the presence of met 5-enkephalin receptors on the plasma membrane of Deiters' neurons and their modulation of GABA transport

Met 5-enkephalin blocks the active transport of GABA across plasma membranes of rabbit Deiters' neurons prepared by microdissection. Such an effect is receptor-mediated, being reversed by the antagonist Naloxone. This result shows that Deiters' neurons bear enkephalin receptors, and sugges...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of neuroscience research 1981, Vol.6 (5), p.579-583
Hauptverfasser:	Cupello, A, Hydén, H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Transport - drug effects Cell Membrane - metabolism Endorphins - pharmacology Enkephalin, Methionine Enkephalins - metabolism Enkephalins - pharmacology gamma-Aminobutyric Acid - metabolism Naloxone - pharmacology Neurons - metabolism Rabbits Receptors, Opioid - metabolism Space life sciences Vestibular Nuclei - metabolism Vestibular Nucleus, Lateral - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Met 5-enkephalin blocks the active transport of GABA across plasma membranes of rabbit Deiters' neurons prepared by microdissection. Such an effect is receptor-mediated, being reversed by the antagonist Naloxone. This result shows that Deiters' neurons bear enkephalin receptors, and suggests a hypothesis on the mechanism of enkephalin-mediated neuronal inhibition.
ISSN:	0360-4012
DOI:	10.1002/jnr.490060504