The Effect of RES Blockade on Red Blood Cell Survival

UCHIDA, T., MATSUDA, S., TANAKA, T., SATO, T., YUI, T., KOKUBUN, R., KUMANO, M. and KARIYONE, S. The Effect of RES Blockade on Red Blood Cell Survival. Tohoku J. exp. Med., 1981, 135 (3), 247-253-The effect of RES blockade on the survival of heat-damaged and antibody coated red blood cells was evaluated in C3H mice. RES function of C3H mice was determined by the survival of 59Fe-labeled, heat-damaged red blood cells at 49°C for 30min. When animals were treated with an intravenous injection of non-labeled, heat-damaged red blood cells for the blockade of RES, red blood cell destruction was depressed in non-splenectomized and splenectomized mice. In the survival or organ distribution of 59Fe-labeled, antibody-coated red blood cells, no difference was noted between animals with and without blockade. These findings suggest that heat-damaged red blood cells were destructed predominantly in the splenic RES and antibody coated cells were not broken down only by the splenic RES.