Neurotransmitter accumulation and calcium-dependent release from different regions of rat brain

Neurotransmitter accumulation and calcium-dependent release from different regions of rat brain

High affinity accumulation and calcium-dependent release of 3H-NE, 3H-dopamine, 14C-GABA and 14C-choline/ACh were investigated in 12 regions of the rat brain. Regional differences in accumulation and fractional calcium-dependent release were observed for all four substances. The corpus striatum exhi...

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Veröffentlicht in:Life sciences (1973) 1977-12, Vol.21 (12), p.1837-1843
Hauptverfasser: Haycock, John W., Meligeni, John A.
Format: Artikel
Sprache:eng
Schlagworte:
Acetylcholine - metabolism
Animals
Brain - drug effects
Brain - metabolism
Calcium - pharmacology
Choline - metabolism
Dopamine - metabolism
gamma-Aminobutyric Acid - metabolism
Neurotransmitter Agents - metabolism
Norepinephrine - metabolism
Rats
Tissue Distribution
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Zusammenfassung:High affinity accumulation and calcium-dependent release of 3H-NE, 3H-dopamine, 14C-GABA and 14C-choline/ACh were investigated in 12 regions of the rat brain. Regional differences in accumulation and fractional calcium-dependent release were observed for all four substances. The corpus striatum exhibited particularly high accumulation values and high release rates for all four substances. Caudal structures exhibited low accumulation and release values. The differences are discussed in terms of possible differences in neurotransmitter dynamics in the different regions.
ISSN:0024-3205
1879-0631
DOI:10.1016/0024-3205(77)90166-7