Pharmacological Studies on Experimental Nephritic Rats (10) Changes in Coagulation-fibrinolysis System in the Course of Anti-GBM Induced Nephritis

In order to elucidate a role of coagulation-fibrinolysis system in glomerulonephritis, we investigated changes in blood clotting time and fibrinolytic activity in plasma, urine and renal cortex during a process of anti-GBM induced nephritis in rats. 1, Fibrinogen level in plasma remarkably increased from the day after the injection of anti-GBM serum (the 1st day), reached a peak on the 20th day and then decreased with time course. 2. Although recalcification time and partial thromboplastin time were temporally prolonged on the 5th day, they were conversely shortened after the 10th day, that is, the acceleration of coagulation was seen and maintained for long terms. 3. Fibrinolytic activity in plasma [plasminogen (Plg) ] was not altered throughout the 80 day exm perimental periods. On the other hand, fibrinolytic activities in urine (plasmin and Plg activator) and renal cortex (Pig activator) pronouncedly rose from the 1st day and attained to their peaks about the 10th day. Thereafter, these fibrinolytic activities rapidly reduced and reverted to almost normal levels by the 30th or the 40th day.