Etorphine and shuttle-box self-stimulation in the rat

Rats were trained to turn rewarding electrical brain stimulation on and off by crossing back and forth in a shuttle-box. Moderate doses of the narcotic analgesic, etorphine, increased mean ON times while having little effect on OFF times. Tolerance did not develop to the reward enhancement action ov...

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Veröffentlicht in:	Pharmacology, biochemistry and behavior biochemistry and behavior, 1977-11, Vol.7 (5), p.413-416
Hauptverfasser:	Baltzer, John H., Levitt, Robert A., Furby, John E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Dose-Response Relationship, Drug Drug Tolerance Electric Stimulation Etorphine Etorphine - pharmacology Female Hypothalamus - drug effects Male Morphinans - pharmacology Narcotics Rats Reward Self Stimulation - drug effects Self-stimulation Shuttle-box
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Zusammenfassung:	Rats were trained to turn rewarding electrical brain stimulation on and off by crossing back and forth in a shuttle-box. Moderate doses of the narcotic analgesic, etorphine, increased mean ON times while having little effect on OFF times. Tolerance did not develop to the reward enhancement action over five consecutive days of injections. This paradigm seems valuable for exploration of the reinforcing properties of narcotic drugs.
ISSN:	0091-3057 1873-5177
DOI:	10.1016/0091-3057(77)90207-6