Brain metabolism of amino acids and ammonia in patients with chronic renal insufficiency

Brain metabolism of amino acids and ammonia in patients with chronic renal insufficiency. The cerebral metabolism of amino acids (AA) and ammonia in the postabsorptive state was evaluated in 8 subjects with normal renal function and in 6 patients with chronic renal insufficiency (CRI) by measuring the differences between the arterial and the internal jugular venous concentrations of free AA and ammonia. In normal conditions, the brain extracts serine, glutamine, proline, glycine, valine, ½cystine, isoleucine, leucine, and lysine. In CRI, cerebral glycine and ½cystine uptake increases, valine and isoleucine extraction decreases, glutamine uptake disappears, and ammonia extraction becomes evident. The cerebral extraction of glycine is correlated with the arterial concentration of glycine, serine, and branched-chain AA. The extraction of ½cystine is correlated with the arterial concentration of ½cystine and tyrosine. Finally, the extractions of valine and ammonia are correlated with the arterial concentration of valine and ammonia, respectively. It follows that alterations of blood AA and ammonia concentrations observed in CRI markedly affect the cerebral uptake of some AA and ammonia. The lack of cerebral glutamine extraction might be due to an enhanced production and/or, more likely, to an impaired utilization of this AA by the brain. Data reported here suggest that in CRI cerebral nitrogen metabolism is altered; such alterations may play a pathogenic role in uremic encephalopathy. Métabolisme cérébral des acides aminés et de l'ammoniaque chez les malades atteints d'insuffisance rénale chronique. Le métabolisme cérébral des acides aminés (AA) et de l'ammoniaque dans la phase post absorption a été étudié chez 8 sujets ayant une fonction rénale normale et 6 malades atteints d'insuffisance rénale chronique par la mesure de la différence de concentration artério-vieneuse jugulaire interne des AA et de l'ammoniaque. Dans les conditions normales le cerveau extrait la serine, la glutamine, la proline, la glycine, la valine, la ½ cystine, l'isoleucine, la leucine et la lysine. Dans l'insuffisance rénale chronique la captation cérébrale de glycine et de ½ cystine augmente, l'extraction de valine et d'isoleucine diminue, la captation de glutamine disparait et l'extraction d'ammoniaque devient évidente. L'extraction cérébrale de glycine est corrélée à la concentration artérielle de glycine, de serine et des AA à chaine latérale. L'extraction de la ½ cystine est corrél