Patterns of relapse in stages I, II and IIIA Hodgkin's disease: Influence of initial therapy and implications for the future

An analysis was undertaken of the patterns of relapse observed among 111 patients with Stages I–IIIA Hodgkin's disease. All had undergone staging laparotomy and then received either extended field irradiation alone (60%) or limited field irradiation followed by MOPP (nitrogen mustard, vincristi...

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Veröffentlicht in:	International journal of radiation oncology, biology, physics biology, physics, 1977-09, Vol.2 (9), p.853-862
Hauptverfasser:	Levi, John A, Wiernik, Peter H, O'Connell, Michael J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Chemotherapy Child Female Hodgkin Disease - pathology Hodgkin Disease - radiotherapy Hodgkin Disease - therapy Hodgkin's disease Humans Lymph Node Excision Male Middle Aged Neoplasm Recurrence, Local - pathology Prognosis Radiotherapy Splenectomy
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Zusammenfassung:	An analysis was undertaken of the patterns of relapse observed among 111 patients with Stages I–IIIA Hodgkin's disease. All had undergone staging laparotomy and then received either extended field irradiation alone (60%) or limited field irradiation followed by MOPP (nitrogen mustard, vincristine, procarbazine and prednisone) chemotherapy. A total of 26 relapses occurred; relapse rates after irradiation alone were 34% but only 7% following irradiation plus adjuvant chemotherapy. The duration of both remission and survival was significantly longer for the patients receiving irradiation plus chemotherapy than for those treated with irradiation alone ( p = < 0.001,
ISSN:	0360-3016 1879-355X
DOI:	10.1016/0360-3016(77)90183-3