Production of autoantibodies by immunization with rabbit transferrin modified at its glycosidic moiety

Rabbit transferrin was modified by the introduction of methionine sulfone hydrazide into either its sialic acid residues or into both its sialic acid and galactosyl residues. Rabbits immunized with the modified transferrin produced antibodies which reacted with the native antigen both in radioimmuno...

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Veröffentlicht in:	Molecular immunology 1981-05, Vol.18 (5), p.367-372
Hauptverfasser:	Barsoum, A.L., Davidson, E.A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autoantibodies - biosynthesis Galactosides Hydrazines Immunodiffusion Immunoelectrophoresis Immunoglobulin G - biosynthesis Methionine - analogs & derivatives Methionine - pharmacology Rabbits Sialic Acids Transferrin - analogs & derivatives Transferrin - immunology
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Zusammenfassung:	Rabbit transferrin was modified by the introduction of methionine sulfone hydrazide into either its sialic acid residues or into both its sialic acid and galactosyl residues. Rabbits immunized with the modified transferrin produced antibodies which reacted with the native antigen both in radioimmunoassay and gel diffusion. Antibodies eluted from a transferrin-Sepharose column gave, in immunoelectrophoresis, a precipitin band specific for IgG.
ISSN:	0161-5890 1872-9142
DOI:	10.1016/0161-5890(81)90097-3