Hepatic First-Pass Effect of Thiazinamium Methylsulfate (N-Methylpromethazine Methylsulfate) in Dogs

Plasma concentration-time curves are described for the intravenous infusion and portal vein infusion of the quaternary ammonium compound thiazinamium methylsulfate to dogs. Comparison of areas under the curve indicate that hepatic first-pass elimination occurred on the order of 25-50%.

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Bibliographische Detailangaben
Veröffentlicht in:	Journal of pharmaceutical sciences 1981-08, Vol.70 (8), p.947-949
Hauptverfasser:	Jonkman, Jan H.G., Westenberg, Herman G.M., Kleyn, Eppo Van Der
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bile - metabolism Biological Availability Dogs First-pass effect-thiazinamium methylsulfate First-pass effect—thiazinamium methylsulfate, dogs, plasma concentration-time curves Liver - metabolism N-Methylpromethazine methylsulfate-hepatic first-pass effect in dogs N-Methylpromethazine methylsulfate—hepatic first-pass effect in dogs, plasma concentration-time curves plasma concentration-time curves Promethazine - analogs & derivatives Promethazine - metabolism Thiazinamium methylsulfate-hepatic first-pass effect in dogs Thiazinamium methylsulfate—hepatic first-pass effect in dogs, plasma concentration-time curves
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Beschreibung
Zusammenfassung:	Plasma concentration-time curves are described for the intravenous infusion and portal vein infusion of the quaternary ammonium compound thiazinamium methylsulfate to dogs. Comparison of areas under the curve indicate that hepatic first-pass elimination occurred on the order of 25-50%.
ISSN:	0022-3549 1520-6017
DOI:	10.1002/jps.2600700831